Searchable abstracts of presentations at key conferences in endocrinology

ea0026p650 | Clinical case reports | ECE2011

Coincidental presence of acromegaly and nonclassical congenital adrenal hyperplasia in a patient with hirsutism: a case report

Gedik Arzu , Muhittin Yalcin Mehmet , Comlekci Abdurrahman

Hirsutism, development of terminal body hair in women in unexpected areas, may result from different etiologies; 4.3% being nonclassical congenital adrenal hyperplasia (NCCAH) and acromegaly being one of the rarests. We here present a severe hirsutism case with acromegaly and NCCAH.Case: A 30-year-old woman with headache and visual field abnormalities was consultated by our clinic about her cranial imaging revealing a macroadenoma in pituitary localizati...

ea0020p23 | Adrenal | ECE2009

IL-6 and osteoprotogerin levels in subjects with non-functioning adrenal adenomas

Yener Serkan , Comlekci Abdurrahman , Yuksel Faize , Comlekci Abdurrahman , Akinci Baris , Demir Tevfik , Yesil Sena

Data regarding cardiovascular risk in subjects with non-functioning adrenal adenoma is limited. The aim of this study is to investigate osteoprotogerin (OPG) and Interleukin-6 (IL-6) levels in subjects with non functioning adrenal incidentalomas.Of 51 subjects without findings of hypercortisolism or other adrenal gland disorders (AI), 32 BMI-unmatched controls (C) and 20 BMI-matched controls (BC) were enrolled. Participants underwent hormonal evaluation ...

ea0041ep2 | Adrenal cortex (to include Cushing's) | ECE2016

Effect of heterophilic antibody interference in ACTH immunoassay to Subclinical Cushing’s Syndrome screening: A pilot study

Yener Serkan , Ozisik Seciil , Cavdar Umit , Demirpence Mustafa , Comlekci Abdurrahman

Heterophilic antibodies are well-known interferent factors affecting most immunoassays. However, they have been poorly evaluated in routine clinical practice. Definition of Subclinical Cushing’s Syndrome (SCs) has been arbitrary and prevalence has shown significant variations related with the diversity of the diagnostic tests. In most of the guidelines a low or suppressed corticothropin (ACTH) level has been suggested as an important predictor of SCs. Here, we sought to i...

ea0037ep723 | Pituitary: clinical | ECE2015

Determinants of neutrophil/lymphocyte ratio in acromegaly patients

Yilmaz Merve , Gedik Arzu , Demir Tevfik , Cimrin Dilek , Comlekci Abdurrahman

Introduction: Neutrophil/lymphocyte ratio (NLR) is an indicative of the acute phase response. It is a significant indicator of the systemic inflammation, and considered as a poor prognosis indicator in various disease. We aimed to evaluate NLR and its determinants in acromegaly patients.Patients and methods: A retrospective chart review of 40 patients with acromegaly and 45 age and sex matched healthy individuals was performed. Patients with active infec...

ea0056p227 | Calcium & Vitamin D metabolism | ECE2018

Acquired Fanconi syndrome and hypophosphatemic osteomalacia in two patients treated with adefovir and tenofovir

Saydam Basak Ozgen , Bengi Goksel , Yener Serkan , Comlekci Abdurrahman

Background: Proximal tubule dysfunction in Fanconi syndrome causes impaired reabsorbtion of amino acids, glucose, urate and phosphate, which leads to hypophosphatemic osteomalcia. Adefovir and tenofovir are two nucleoside reverse transcriptase inhibitors, which are used for treatment of patients with hepatitis B infection. Although these drugs are well tolerated with few side effects, patients may rarely suffer from drug-induced Fanconi syndrome and hypophosphatemic osteomalac...

ea0041ep28 | Adrenal cortex (to include Cushing's) | ECE2016

Adenoma size could be an important predictor of Subclinical Cushing’s Syndrome

Yener Serkan , Baris Mustafa , Demirpence Mustafa , Ozisik Secil , Cavdar Umit , Demir Omer , Secil Mustafa , Comlekci Abdurrahman

Subclinical Cushing’s syndrome (SCs) is used to refer to an adrenal incidentaloma with subtle autonomous cortisol secretion and without typical signs and symptoms of hypercortisolism. Diagnostic criteria are uncertain and arbitrary. In this study we aimed to investigate the power of adenoma size as an independent predictor of SCs.Dokuz Eylul University Adrenal Tumours Study Group database includes 596 patients by January 2016. Briefly, there are 332...

ea0037ep231 | Calcium and Vitamin D metabolism | ECE2015

Is there a relationship between neutrophil/lymphocyte ratio and vitamin D levels in individuals over 65 years of age?

Yilmaz Merve , Gedik Arzu , Demir Tevfik , Eraydin Ayten , Cimrin Dilek , Comlekci Abdurrahman , Eraslan Sevinc

Introduction: Vitamin D deficiency may be an important predisposing factor for infections as well as autoimmune diseases in old individuals. Neutrophil/lymphocyte ratio (NLR), is a meaningful indicator of inflammation throughout the body. In this study we aimed to show, whether or not a relationship exists between vitamin D levels and NLR in patients older than 65 years.Materials and method: Data of 82 patients over 65 years of age was retrospectively ex...

ea0032p629 | Growth hormome IGF axis – basic | ECE2013

Determinants of carotid intima media thickness in acromegaly patients

Yilmaz Merve , Gedik Arzu , Basaloglu Can , Cimrin Dilek , Ellidokuz Hulya , Secil Mustafa , Comlekci Abdurrahman

Introduction: Acromegaly is a rare disease characterized by GH and IGF1 hypersecretion and increased cardiovascular mortality. Ultrasonographic measurement of carotid intima media thickness (CIMT) gives substantial information about early atherosclerosis. We aimed to evaluate CIMT and its determinants in a group of acromegaly patient.Patients and methods: Forty-four acromegaly patient and 43 age, sex and body mass index (BMI) matched healthy controls wer...

ea0032p904 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Clinical, hormonal and radiological characteristics of a group of primary empty sella patients

Gedik Arzu , Yilmaz Merve , Demir Tevfik , Bayraktar Firat , Men Suleyman , Eraslan Sevinc , Comlekci Abdurrahman

Background: Primary empty sella is an anatomical term defining the herniation of subarachnoid space within the sella turcica without an underlying factor such as pituitary tumor, surgery, irradiation or trauma.Patients and methods: We retrospectively evaluated clinical, hormonal and radiological data of the patients with primary empty sella syndrome followed in our institution between 2001 and 2012.Results: Ninety-four patients (80...

ea0032p912 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Prevalance of cancer in acromegaly patients; a single center data

Gedik Arzu , Yilmaz Merve , Demir Tevfik , Yener Serkan , Bayraktar Firat , Eraslan Sevinc , Comlekci Abdurrahman

Introduction: The growth promoting effects of GH and IGF1 has lead to increasing number of cancer surveillence studies in acromegaly so far. We herein aimed to present the prevalance of cancer in acromegaly patients followed in our institution.Patients and design: We retrospectively analyzed medical records of 151 patients with acromegaly (83 females) followed in our department from 2001 to 2012.Results: Overall, cancer was detecte...